Google maps: 

Subway: Grand Central Station (Shuttle, 4, 5,6, and 7 train) is the closest subway stop, 53rd & Lexington stop (E train) and 51st St (6 train) are only a little further. They are all between 10-15 minute walk. ​

Bus: The M15 bus runs uptown on 1st Avenue. There is an express stop at 1st Ave & E 42nd Street and a local stop at 1st Ave & E 45th Street. The M15 also runs downtown on 2nd Avenue. ​

Parking: There are paid lots on E 46th between 1st & 2nd Ave and E 45th between 2nd & 3rd Ave.