COVID-19 vaccines COVID vaccines are there to protect people from getting a very serious illness. There are several different vaccines around the world which can prevent people from getting COVID-19. All vaccines have been tested on a large number of people to check they are safe and they are effective at preventing the illness. As far as we are aware from our global contacts, there are no adverse effects of having the vaccine that specifically relate to people with Down syndrome. If anyone has concerns about getting the vaccine, they should think about the danger of getting the illness and any concerns should be discussed with their doctor who can provide them with information. In an interview by Katie Matthews, who has Down syndrome, Dr Roger Banks from the UK NHS England Learning Disability and Autism Programme provides some helpful information about: What is a vaccine; How are vaccinations made; Why you should get a vaccine; How you should decide whether to get a vaccine. The effect of the vaccine in people with Down syndrome A published research study has shown that adults with Down syndrome produce fewer antibodies after two coronavirus vaccinations (Moderna, Pfizer or AstraZeneca) compared to people without Down syndrome. All adult participants produced antibodies four weeks after the two COVID vaccinations. The antibody concentrations in adults with Down syndrome are lower than in people without Down syndrome. This effect was seen after the mRNA vaccinations, Moderna or Pfizer, but also after AstraZeneca vaccination. In addition, it was found that after a Moderna or Pfizer vaccination, the antibody concentration decreased with increasing age. The results have been presented to the Netherlands Health Council in the form of an advisory report. Based on this advisory report, among other things, the Health Council has decided to offer people with Down syndrome additional vaccinations. You can read the full article published in the Journal of Infectious DIseases here: Full article Manage Cookie Preferences